Abstract
The novel SUN-domain family of nuclear envelope proteins interacts with various KASH-domain partners to form SUN-domain-dependent 'bridges' across the inner and outer nuclear membranes. These bridges physically connect the nucleus to every major component of the cytoskeleton. SUN-domain proteins have diverse roles in nuclear positioning, centrosome localization, germ-cell development, telomere positioning and apoptosis. By serving both as mechanical adaptors and nuclear envelope receptors, we propose that SUN-domain proteins connect cytoplasmic and nucleoplasmic activities.
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Acknowledgements
We gratefully acknowledge support from the Israel Science Foundation (ISF), Israel–USA Binational Science Foundation (BSF) and the European Union's FP6, Life Science, Genomics and Biotechnology for Health to Y.G., and the National Institutes of Health to K.L.W.
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Tzur, Y., Wilson, K. & Gruenbaum, Y. SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton. Nat Rev Mol Cell Biol 7, 782–788 (2006). https://doi.org/10.1038/nrm2003
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DOI: https://doi.org/10.1038/nrm2003
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