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Innate immunity

Peroxisomes pack a distinct punch

Nature Reviews Immunology volume 14, pages 516–517 (2014)Cite this article

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induction of type I and type III IFNs is differentially regulated by distinct intracellular organelles

RIG-I-like receptors (RLRs) are a family of innate immune receptors that are activated by nucleic acids and promote antiviral immunity through the induction of type I interferons (IFNs). Odendall et al. now report that RLRs also induce the expression of type III IFNs in response to intracellular infection. They show that RLR-mediated induction of type I and type III IFNs is differentially regulated by distinct intracellular organelles, and they identify peroxisomes as a major site of type III IFN expression.

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References

  1. Odendall, C. et al. Diverse intracellular pathogens activate type III interferon expression from peroxisomes. Nature Immunol. http://dx.doi.org/10.1038/ni.2915 (2014)

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  1. Yvonne Bordon
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Bordon, Y. Peroxisomes pack a distinct punch. Nat Rev Immunol 14, 516–517 (2014). https://doi.org/10.1038/nri3718

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