Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Vaccines

Foes of fungi are just 17

Nature Reviews Immunology volume 11, pages 74–75 (2011)Cite this article

Subjects

In initial experiments, the authors showed that a protective vaccine against B. dermatitidis induced both antigen-specific interferon-γ (IFNγ)-producing TH1 cells and interleukin-17 (IL-17)-producing TH17 cells in mice. Following pulmonary infection with B. dermatitidis, TH1 and TH17 cells were rapidly recruited to the lungs of vaccinated, but not unvaccinated, mice. Most of the vaccinated animals cleared the infection within 6 days; however, unvaccinated mice could not clear B. dermatitidis and were moribund by day 15.

Interestingly, antibody-mediated blockade of IL-17 inhibited the ability of vaccinated mice to clear B. dermatitidis more profoundly than blockade of IFNγ. Furthermore, despite developing normal TH1-type immune responses, vaccinated mice that were deficient in IL-17 or the IL-17 receptor (IL-17R) were not protected from pulmonary B. dermatitidis infection. By contrast, mice that were deficient in molecules necessary for TH1-type immunity, including T-bet and IL-12R, were protected from subsequent B. dermatitidis infection following vaccination. Importantly, in each of the experiments, vaccine-induced TH17 cells promoted protective antifungal immunity without inducing immunopathology in the lungs.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

ORIGINAL RESEARCH PAPER

  1. Wüthrich, M. et al. Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice. J. Clin. Invest. 4 Jan 2011 (doi: 10.1172/JCI43984)

    Article  Google Scholar 

Download references

Authors
  1. Yvonne Bordon
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bordon, Y. Foes of fungi are just 17. Nat Rev Immunol 11, 74–75 (2011). https://doi.org/10.1038/nri2929

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nri2929

Search

Advanced search

Quick links

Nature Briefing Microbiology

Sign up for the Nature Briefing: Microbiology newsletter — what matters in microbiology research, free to your inbox weekly.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing: Microbiology