A prospective multicentre study investigated the efficacy of optimized triple therapy (OPT-TRI; esomeprazole, amoxicillin, clarithromycin) versus nonbismuth quadruple concomitant therapy (OPT-CON; OPT-TRI regimen plus metronidazole) for Helicobacter pylori infection. The OPT-CON regimen achieved substantially higher (>90%) H. pylori eradication rates than OPT-TRI. Mild-to-moderate adverse events, which did not affect compliance, were more common in the OPT-CON than the OPT-TRI treatment group.
References
Molina-Infante, J. et al. Optimised empiric triple and concomitant therapy for Helicobacter pylori eradication in clinical practice: the OPTRICON study. Aliment. Pharmacol. Ther. 10.1111/apt.13069
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Optimizing treatment of Helicobacter pylori infection. Nat Rev Gastroenterol Hepatol 12, 123 (2015). https://doi.org/10.1038/nrgastro.2015.18
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DOI: https://doi.org/10.1038/nrgastro.2015.18
