The development of thiopurine-induced pancreatitis in patients with IBD has been linked to the HLA-DQA1*02:01–HLA-DRB1*07:01 haplotype (rs2647087). The association was identified by genome-wide analysis of 172 patients and was validated in a separate cohort (n = 78). Patients with IBD who are heterozygous or homozygous at rs2647087 have a 9% and 17% risk of pancreatitis after thiopurine treatment, respectively.
References
Heap, G. A. et al. HLA-DQA1–HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants. Nat. Genet. doi:10.1038/ng.3093
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The HLA-DQA1–HLA-DRB1 haplotype is linked to risk of thiopurine-induced pancreatitis in IBD. Nat Rev Gastroenterol Hepatol 11, 642 (2014). https://doi.org/10.1038/nrgastro.2014.172
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DOI: https://doi.org/10.1038/nrgastro.2014.172
