Haid et al. have identified a flavenoid that inhibits post-attachment entry of HCV and prevents infection of primary human hepatocytes. The previously unreported antiviral activity of ladanein (BJ486K) is effective against all major HCV genotypes. A synergistic effect was achieved by combining ladanein with ciclosporin—as such, the authors believe that flavanoid derivatives have potential as part of combined treatment, for example, in transplant recipients.
ORIGINAL RESEARCH PAPER
Haid, S. et al. A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes. Gastroenterology doi:10.1053/j.gastro.2012.03.036
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Ladanein inhibits HCV entry into human hepatocytes irrespective of genotype. Nat Rev Gastroenterol Hepatol 9, 302 (2012). https://doi.org/10.1038/nrgastro.2012.84
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DOI: https://doi.org/10.1038/nrgastro.2012.84