Mönnikes et al. gave pantoprazole to 626 reflux oesophagitis patients for up to 16 weeks to see if it could sustain GERD healing and treat symptoms resembling IBS and functional dyspepsia (FD). Pantoprazole treatment significantly lowered rates of reflux oesophagitis along with reflux symptoms and symptoms of IBS and FD. During a 6-month no-treatment observation period, the low IBS and FD rates achieved were maintained, but rates of reflux signs or symptoms increased.
ORIGINAL RESEARCH PAPER
Mönnikes, H. et al. Randomised clinical trial: sustained response to PPI treatment of symptoms resembling functional dyspepsia and irritable bowel syndrome in patients suffering from an overlap with erosive gastro-oesophageal reflux disease. Aliment. Pharmacol. Ther. doi:10.1111/j.1365-2036.2012.05085.x
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Pantoprazole successfully treats symptoms suggestive of IBS and functional dyspepsia in patients with erosive GERD. Nat Rev Gastroenterol Hepatol 9, 302 (2012). https://doi.org/10.1038/nrgastro.2012.82
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DOI: https://doi.org/10.1038/nrgastro.2012.82
