Inhibition of type I IL-1 receptor (IL-1R1) could have potential as a treatment for alcoholic liver disease, according to the findings of Petrasek et al. Their work in mice has shown that the development of liver steatosis, inflammation and injury induced by alcohol requires proinflammatory cytokine IL-1β and signalling by IL-1R1 to be upregulated via caspase 1, a component of the inflammasome. In vivo, a recombinant IL-1R antagonist blocked IL-1 signalling and ameliorated alcohol-induced liver steatosis, inflammation and injury.
ORIGINAL RESEARCH PAPER
Petrasek J. et al. IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice. J. Clin. Invest. doi:10.1172/JCI60777
Rights and permissions
About this article
Cite this article
Essential role for IL-1 receptor in the pathogenesis of alcoholic liver disease via inflammasome activation. Nat Rev Gastroenterol Hepatol 9, 616 (2012). https://doi.org/10.1038/nrgastro.2012.191
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrgastro.2012.191
