Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Essay
  • Published:

Heredity before genetics: a history

Abstract

Two hundred years ago, biologists did not recognize that there was such a thing as 'heredity'. By the 1830s, however, insights from medicine and agriculture had indicated that something is passed from generation to generation, creating the context for the brilliant advances of Mendel and Darwin. Recent work on the history and philosophy of science has shed light on how seventeenth-, eighteenth- and nineteenth-century thinkers sought to understand similarities between parents and offspring.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Leeuwenhoek's illustration of spermatozoa.
Figure 2: The frontispiece to Harvey's De Generatione Animalium.
Figure 3: Polydactyly.
Figure 4: A New Leicester sheep.
Figure 5: Number of French medical theses on hereditary illnesses, 1650–1800.

References

  1. Mueller-Wille, S. & Rheinberger, H. -J. Heredity — the Production of an Epistemic Space Vol 276 (Max-Planck-Institut für Wissenschaftsgeschichte, Berlin, 2004).

    Google Scholar 

  2. Bowler, P. J. The Mendelian Revolution: The Emergence of Hereditarian Concepts in Modern Science and Society (Athlone, London, 1989).

    Google Scholar 

  3. Blackledge, C. The Story of V (Weidenfeld & Nicolson, London, 2003).

    Google Scholar 

  4. Malinowski, B. The Sexual Life of Savages in North-Western Melanesia (Routledge & Kegan Paul, London, 1932).

    Google Scholar 

  5. Furth, C. A Flourishing Yin: Gender in China's Medical History, 960–1665 (California Univ. Press, Berkeley, 1999).

    Google Scholar 

  6. Cobb, M. The Egg and Sperm Race: The Seventeenth Century Scientists Who Unravelled the Secrets of Life, Sex and Growth (Free, London, 2006).

    Google Scholar 

  7. Roger, J. The Life Sciences in Eighteenth-Century French Thought (Stanford Univ. Press, Stanford, 1997).

    Google Scholar 

  8. Harvey, W. Disputations Touching the Generation of Animals (Translated by G. Whitteridge) (Blackwell, Oxford, 1981).

    Google Scholar 

  9. Leeuwenhoek to Wren (16 July 1683) in The Collected Letters of Antoni van Leeuwenhoek Vol. 5 (Swets & Zeitlinger, Amsterdam, 1957).

  10. Drake, J. Anthropologia Nova; or, A New System of Anatomy (unknown publisher, London, 1707).

    Google Scholar 

  11. Müller-Wille, S. in A Cultural History of Heredity I: 17th and 18th Centuries Vol 222 (Max-Planck-Institut für Wissenschaftsgeschichte, Berlin, 2002).

    Google Scholar 

  12. Ratcliff, M. J. in A Cultural History of Heredity I: 17th and 18th Centuries Vol 222 (Max-Planck-Institut für Wissenschaftsgeschichte, Berlin, 2002).

    Google Scholar 

  13. Gayon, J. in Lamarck, Philosophe de la Nature (eds Corsi, P., Gayon, J., Gohau, G. & Tirard, S.) (Presses Univ. France, Paris, in the press) (in French).

  14. de Maupertuis, P. -L. M. Vénus Physique (unknown publisher, 1745) (in French).

    Google Scholar 

  15. Terrall, M. in A Cultural History of Heredity I: 17th and 18th Centuries Vol 222 (Max-Planck-Institut für Wissenschaftsgeschichte, Berlin, 2002).

    Google Scholar 

  16. Sandler, I. Pierre Louis Moreau de Maupertuis — a precursor of Mendel? J. Hist. Biol. 16, 101–136 (1983).

    Article  CAS  Google Scholar 

  17. Blundeville, T. The Fower Cheifyst Offices Belongyng to Horsemanshippe (Seres, London, 1566).

    Google Scholar 

  18. Russell, N. Like Engend'ring Like: Heredity and Animal Breeding in Early Modern England (Cambridge Univ. Press, Cambridge, 1986).

    Google Scholar 

  19. Columella, L. J. M. Of Husbandry in Twelve Books (Millar, London, 1745).

    Google Scholar 

  20. Wood, R. J. & Orel, V. Genetic Prehistory in Selective Breeding: a Prelude to Mendel (Oxford Univ. Press, Oxford, 2001).

    Google Scholar 

  21. Wood, R. J. & Orel, V. Scientific breeding in Central Europe during the early nineteenth century: background to Mendel's later work. J. Hist. Biol. 38, 239–272 (2005).

    Article  Google Scholar 

  22. Stubbe, H. History of Genetics: From Prehistoric Times to the Rediscovery of Mendel's Laws (MIT Press, London, 1972).

    Google Scholar 

  23. Gayon, J. in The Concept of the Gene in Development and Evolution: Historical and Epistemological Perspectives (eds Buerton, P., Falk, R. & Rheinberger, H.-J.) 69–90 (Cambridge Univ. Press, Cambridge, 2000).

    Book  Google Scholar 

  24. Bacon, F. Historie Naturall and Experimentall, of Life and Death (Lee & Mosley, London, 1638).

    Google Scholar 

  25. López-Beltrán, C. Forging heredity: from metaphor to cause, a reification story. Stud. Hist. Philos. Sci. 25, 211–235 (1994).

    Article  Google Scholar 

  26. López-Beltrán, C. Les maladies héréditaires: 18th century disputes in France. Rev. Hist. Sci. [Paris] 48, 307–350 (1995).

    Article  Google Scholar 

Download references

Acknowledgements

Thanks to the two anonymous referees.

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The author declares no competing financial interests.

Related links

Related links

FURTHER INFORMATION

The Egg & Sperm Race web site

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cobb, M. Heredity before genetics: a history. Nat Rev Genet 7, 953–958 (2006). https://doi.org/10.1038/nrg1948

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrg1948

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing