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A new approach to the distribution and storage of genetic resources

Abstract

Large-scale genome, transcriptome and proteome projects are rapidly producing new information, databases and physical resources that need to be delivered to the biomedical community in a quick and efficient way. Information and databases can be made available online but there was, until recently, no standardized means of widely distributing physical resources. However, the technology required is now available and the way laboratory researchers work might never be the same again.

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Figure 1: The DNA printer.
Figure 2: Comparison of distribution of clones that uses a traditional dry ice box with distribution that uses DNA printing technology.

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Acknowledgements

We thank S. Fukuda, K. Imamura, K. Imotani, M. Kanamori, T. Kasukawa, S. Katayama, F. Kawabata, T. Kawashima, Y. Kitazume, M. Nakamura, H. Sano, T. Sasaki, Y. Sumita, H. Suzuki, Y. Takeda and Y. Chen Choo for their technical support; T. Hayashi, H. Himei, H. Isaka, Y. Shigemoto, A. Suzuki, K. Suzuki, A. Tomotsugu and H. Torigoe for their secretarial support; and K.K. Dnaform for their self-financed cooperation. We especially thank J. Mattick and J. Gough for their editorial assistance. We also thank RIKEN executives, and the members of Yokohama Research Promotion Division and Technology Transfer and Research Coordination Division for administrative support. This work was supported by research grants from the Ministry of Education and Culture (for the RIKEN Genome Exploration Research Project), the Sports, Science and Technology Department of the Japanese Government (to Y.H.), and from the Japan Science and Technology Corporation (to Y.H. for Preventure).

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FURTHER INFORMATION

American Tissue Culture Collection clone collections

CloneSaver Cards

Invitrogen clone collections

MRC Geneservice clone collections

Open Biosystems clone collections

RIKEN Genome Exploration Research Group

RZPD (Deutsches Ressourcenzentrum für Genomforschung) clone collections

Glossary

DNA PRINTER

A machine that is used for spotting DNA on substrate such as paper.

FTA CARD

A chemically treated filter paper that is designed for the collection and storage of biological samples at room temperature for subsequent DNA analysis.

FULL-LENGTH CDNA CLONES

Clones containing the entire fragments of complementary DNAs of mRNA.

LAB-ON-A-CHIP

The technology that is used to perform a combination of analysis on a single miniaturized devise for biological and clinical analysis.

TRANSCRIPTOME

The full complement of activated genes, mRNAs or transcripts in a particular tissue at a particular time.

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Hayashizaki, Y., Kawai, J. A new approach to the distribution and storage of genetic resources. Nat Rev Genet 5, 223–228 (2004). https://doi.org/10.1038/nrg1296

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