Cardiac-specific overexpression of cytochrome P450 2J2 (CYP2J2) protects against diabetic cardiomyopathy induced by a high-fat diet and low-dose streptozotocin in transgenic mice, according to Ma and co-investigators. The researchers show that CYP2J2 overexpression improves cardiac function by reducing plasma glucose and insulin levels and improving glucose tolerance and cardiac glucose uptake. Ma et al. conclude that enhancement of the activation of epoxyeicosatrienoic acids has potential as a therapeutic strategy to prevent diabetic cardiomyopathy.