Cardiac-specific overexpression of cytochrome P450 2J2 (CYP2J2) protects against diabetic cardiomyopathy induced by a high-fat diet and low-dose streptozotocin in transgenic mice, according to Ma and co-investigators. The researchers show that CYP2J2 overexpression improves cardiac function by reducing plasma glucose and insulin levels and improving glucose tolerance and cardiac glucose uptake. Ma et al. conclude that enhancement of the activation of epoxyeicosatrienoic acids has potential as a therapeutic strategy to prevent diabetic cardiomyopathy.
ORIGINAL RESEARCH PAPER
Ma, B. et al. Cardiac-specific overexpression of CYP2J2 attenuates diabetic cardiomyopathy in male streptozotocin-induced diabetic mice. Endocrinology doi:10.1210/en.2012-2166
Rights and permissions
About this article
Cite this article
Diabetic cardiomyopathy is attenuated by CYP2J2 in mice. Nat Rev Endocrinol 9, 442 (2013). https://doi.org/10.1038/nrendo.2013.117
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrendo.2013.117