Membrane repair failure in myocytes after laser injury to these cells or downhill running is significantly higher in mice models of type 1 or type 2 diabetes mellitus than in control mice. This defect, which can lead to more rapid cell death, was also reported in myocytes in culture that were exposed to high glucose concentrations or to advanced glycation end products.
ORIGINAL RESEARCH PAPER
Howard, A. C. et al. A novel cellular defect in diabetes: membrane repair failure. Diabetes doi:10.2337/db11-0851
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Does membrane repair failure underlie diabetic myopathy?. Nat Rev Endocrinol 7, 694 (2011). https://doi.org/10.1038/nrendo.2011.191
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DOI: https://doi.org/10.1038/nrendo.2011.191