Glycemic control for many patients with type 2 diabetes mellitus (T2DM) is elusive, and the adverse effects of treatment, including hypoglycemia and weight gain, are partially culpable. Until recently, glycosuria has been regarded only as a consequence of T2DM, but dapagliflozin employs glycosuria as a mechanism of treatment. Will this paradigm shift gain acceptance?
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Chao, E. Dapagliflozin—redefining treatment of T2DM?. Nat Rev Endocrinol 7, 696–697 (2011). https://doi.org/10.1038/nrendo.2011.177
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DOI: https://doi.org/10.1038/nrendo.2011.177