Short telomeres are a consistent feature of papillary thyroid cancer (PTC), which, in familial cases, is not restricted to tumor tissue, suggesting that familial PTC has a distinct, heritable, genetic background. Relative telomere length was compared between 30 patients with familial PTC and 46 patients with sporadic PTC. Mean relative telomere length in patients with familial PTC was shorter than that found in sporadic PTC tissues. In patients with sporadic but not with familial PTC, the mean relative telomere length in neoplastic thyroid tissue was significantly shorter than that found in normal contralateral tissues and extrathyroidal tissues.
ORIGINAL RESEARCH PAPER
Capezzone, M. et al. Telomere length in neoplastic and nonneoplastic tissues of patients with familial and sporadic papillary thyroid cancer. J. Clin. Endocrinol.Metab. doi:10.1210/jc.2011-1003
Rights and permissions
About this article
Cite this article
Short telomeres are a consistent feature of PTC. Nat Rev Endocrinol 7, 632 (2011). https://doi.org/10.1038/nrendo.2011.171
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrendo.2011.171