How can real-world data from electronic health records be harnessed to improve the effectiveness and efficiency of clinical trials?
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References
Guyatt, G. H. et al. Users' guides to the medical literature. IX. A method for grading health care recommendations. JAMA 274, 1800–1804 (1995).
Selker, H. P. et al. A proposal for integrated efficacy-to effectiveness (E2E) clinical trials. Clin. Pharmacol. Ther. 95, 147–153 (2014).
Ethier, J.-F. et al. A unified structural/terminological interoperability framework based on LexEVS: application to TRANSFoRm. J. Am. Med. Inform. Assoc. 20, 207–216 (2013).
Van Staa, T. P. et al. The opportunities and challenges of pragmatic point-of-care randomised trials using routinely collected electronic records: evaluations of two exemplar trials. Health Technol. Assess. 18, 1–146 (2014).
Lipset, C. H. Engage with research participants about social media. Nature Med. 20, 231 (2014).
Acknowledgements
The author retired as the Director of the Clinical Practice Research Datalink (CPRD) in June 2014 and remains an expert consultant on the CPRD for the UK Medicines and Healthcare products Regulatory Agency (MRHA), but the views here are his own.
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The author was Director of the Clinical Practice Research Datalink (CPRD) until 7 June 2014.
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Parkinson, J. Getting real in clinical trials. Nat Rev Drug Discov 13, 639–640 (2014). https://doi.org/10.1038/nrd4415
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DOI: https://doi.org/10.1038/nrd4415
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