The use of broadly neutralizing antibodies (bnAbs) isolated from HIV-infected individuals in the development of an effective AIDS vaccine has been limited by potency and breadth of protection. Now, Xu et al. report the generation of multi-specific antibodies derived from bnAbs with specificities for three independent HIV-1 envelope determinants: the CD4 binding site, the membrane-proximal external region and the V1V2 glycan site. In contrast to single bnAbs, these trispecific antibodies conferred complete immunity against a mixture of two different simian–human immunodeficiency viruses (SHIVs) in non-human primates.
References
Xu, L. et al. Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques. Science http://dx.doi.org/10.1126/science.aan8630 (2017).
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Crunkhorn, S. Trispecific antibodies block infection. Nat Rev Drug Discov 16, 754 (2017). https://doi.org/10.1038/nrd.2017.208
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DOI: https://doi.org/10.1038/nrd.2017.208