The development of therapeutic bispecific T cell-engaging antibodies, which recruit cytotoxic T cells to tumour cells, has been hampered by manufacturing challenges as well as their short serum half-life. To circumvent these issues, Stadler et al. generated 1-methylpseudouridine-containing mRNAs encoding bispecific antibodies directed against the T cell receptor-associated molecule CD3 and a tumour-associated antigen. In mice, injected antibody-encoding mRNAs achieved sustained therapeutic antibody levels and safely eliminated tumours in human ovarian carcinoma xenograft models.
References
Stadler, C. et al. Elimination of large tumors in mice by mRNA-encoded bispecific antibodies. Nat. Med. 23, 815–817 (2017)10.1038/nm.4356
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Crunkhorn, S. mRNA-encoded bispecific antibodies eliminate tumours. Nat Rev Drug Discov 16, 530 (2017). https://doi.org/10.1038/nrd.2017.145
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DOI: https://doi.org/10.1038/nrd.2017.145