Despite improvements in the treatment of cardiovascular diseases, the prognosis of heart failure remains poor. To identify potential novel therapeutic targets, Tsuda et al. analyzed G-protein-coupled receptor (GPCR) expression in mouse cardiomyocytes 2 weeks following transverse aortic constriction (TAC) and identified markedly increased expression of corticotropin-releasing hormone receptor 2 (CRHR2). Mice with cardiomyocyte-specific deletion of Crhr2 were protected from TAC-induced cardiac dysfunction, whereas mice treated with the CRHR2 antagonist antisauvagine-30, one week after TAC surgery, did not develop heart failure.
References
Tsuda, T. et al. Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction. J. Exp. Med. 214, 1877–1888 (2017)10.1084/jem.20161924
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Crunkhorn, S. CRHR2 blockade prevents heart failure. Nat Rev Drug Discov 16, 530 (2017). https://doi.org/10.1038/nrd.2017.142
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DOI: https://doi.org/10.1038/nrd.2017.142