An investigation using whole-genome sequencing and copy-number variation analysis of 100 pancreatic ductal adenocarcinomas has identified several new candidate genes that might act as 'drivers' of pancreatic carcinogenesis. These candidates include PIP3-dependent RAC1 guanine nucleotide exchange factor (PREX2) and lysine-specific demethylase 6A (KDM6A). A substantial number of the tumours analysed had focal amplifications of targetable oncogenes (such as HER2, MET and FGFR1); however, none of these specific amplifications was highly prevalent.
References
Waddell, N. et al. Whole genomes redefine the mutational landscape of pancreatic cancer. Nature 518, 495–501 (2015)
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New genomic alterations detected in pancreatic cancer. Nat Rev Clin Oncol 12, 312 (2015). https://doi.org/10.1038/nrclinonc.2015.57
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DOI: https://doi.org/10.1038/nrclinonc.2015.57