An investigation using whole-genome sequencing and copy-number variation analysis of 100 pancreatic ductal adenocarcinomas has identified several new candidate genes that might act as 'drivers' of pancreatic carcinogenesis. These candidates include PIP3-dependent RAC1 guanine nucleotide exchange factor (PREX2) and lysine-specific demethylase 6A (KDM6A). A substantial number of the tumours analysed had focal amplifications of targetable oncogenes (such as HER2, MET and FGFR1); however, none of these specific amplifications was highly prevalent.