Neuroblastoma is responsible for 15% of cancer deaths in children younger than 5 years of age. Because of its heterogeneous clinical course (from spontaneous regression to incurable high-risk disease), it is essential to stratify patients so that the right course of action can be taken. Viprey et al. have identified three types of mRNAs (PHOX2B, tyrosine hydroxylase [TH], and doublecortin [DCX]) that can be detected in peripheral blood and bone marrow. In a cohort of 290 children, high levels of these mRNAs at diagnosis identified those children with ultra high-risk disease who would benefit from new and more-aggressive treatments.
References
Viprey, V. F. et al. Neuroblastoma mRNAs predict outcome in children with stage 4 neuroblastoma: a European HR-NBL1/SIOPEN study. J. Clin. Oncol. 10.1200/JCO.2013.53.3604
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Identifying aggressive neuroblastoma. Nat Rev Clin Oncol 11, 240 (2014). https://doi.org/10.1038/nrclinonc.2014.49
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DOI: https://doi.org/10.1038/nrclinonc.2014.49
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