Evidence has indicated that daily aspirin use reduces cancer risk, especially for colorectal cancer (CRC), but the benefit of alternate-day dosing is unclear. In a long-term observational follow-up study of a randomized trial in more than 33,600 women, use of alternate-day low-dose aspirin was associated with a reduced risk for CRC. Although the study limitations included that not all women received extended follow-up and ascertainment bias could not be ruled out, these data indicate a positive effect for low-dose alternate-day aspirin use for CRC prevention.
References
Cook, N. R. et al. Alternate-day, low-dose aspirin and cancer risk: long-term observational follow-up of a randomized trial. Ann. Intern. Med. 159, 77–85 (2013)
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Benefit for low-dose, alternate-day aspirin use for CRC. Nat Rev Clin Oncol 10, 487 (2013). https://doi.org/10.1038/nrclinonc.2013.143
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DOI: https://doi.org/10.1038/nrclinonc.2013.143