Abiraterone plus prednisone prolongs overall survival relative to prednisone alone in patients with metastatic castration-resistant prostate cancer who have disease progression after treatment with docetaxel. The survival gain observed in this pivotal trial is accomplished with few adverse events and conclusively demonstrates that patients with castration levels of serum testosterone remain sensitive to additional hormonal manipulation.
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O. Sartor declares he is a consultant for Algeta, Bellicum, Centocor Biotech, Dendreon, Exelixis, GlaxoSmithKline, Medivation, Millinium/Takeda, Oncogenex, Pfizer, Sanofi-aventis and Teva. He declares he receives honoraria from Sanofi-aventis and Research Grants from Algeta, Centocor Biotech, Cougar, Dendreon, Exilixis, Millenium/Takeda, Sanofi-aventis and Serono. He also owns shares from Lilly and GlaxoSmithKline.
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Sartor, O. Abiraterone prolongs survival in metastatic prostate cancer. Nat Rev Clin Oncol 8, 515–516 (2011). https://doi.org/10.1038/nrclinonc.2011.111
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DOI: https://doi.org/10.1038/nrclinonc.2011.111
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