The diagnosis of unexplained cardiac arrest could soon become obsolete, as so-called molecular autopsy can now be used to identify its underlying causes. The current view of this subject is discussed, and some personal opinions are presented on the assessment of survivors of sudden cardiac arrest and relatives of individuals who do not survive.
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References
Priori, S. G. et al. Unexplained cardiac arrest. The need of a prospective registry. Eur. Heart J. 13, 1445–1446 (1992).
Krahn, A. D. et al. Systematic assessment of patients with unexplained cardiac arrest: Cardiac Arrest Survivors with Preserved Ejection Fraction Registry (CASPER). Circulation 120, 278–285 (2009).
Ackerman, M. J., Tester, D. J. & Driscoll, D. J. Molecular autopsy of sudden unexplained death in the young. Am. J. Forensic Med. Pathol. 22, 105–111 (2001).
Tester, D. J. & Ackerman, M. J. Postmortem long QT syndrome genetic testing for sudden unexplained death in the young. J. Am. Coll. Cardiol. 49, 240–246 (2007).
Tester, D. J. & Ackerman, M. J. The role of molecular autopsy in unexplained sudden cardiac death. Curr. Opin. Cardiol. 21, 166–172 (2006).
Tan, H. L., Hofman, N., van Langen, I. M., van der Wal, A. C. & Wilde, A. A. Sudden unexplained death: heritability and diagnostic yield of cardiological and genetic examination in surviving relatives. Circulation 112, 207–213 (2005).
Behr, E. R. et al. Sudden arrhythmic death syndrome: familial evaluation identifies inheritable heart disease in the majority of families. Eur. Heart J. 29, 1670–1680 (2005).
Rong, B., Napolitano, C., Bloise, R., Monteforte, N. & Priori, S. G. Yield of genetic screening in inherited cardiac channelopathies: how to prioritize access to genetic testing. Circ. Arrhythmia Electrophysiol. 2, 6–15 (2009).
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Priori, S. Unexplained sudden cardiac death—back to clinical evaluation. Nat Rev Cardiol 6, 678–679 (2009). https://doi.org/10.1038/nrcardio.2009.174
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DOI: https://doi.org/10.1038/nrcardio.2009.174
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