Patients with venous thromboembolism receive anticoagulants after a thrombotic episode, usually for a fixed period. Discontinuing treatment could lead to recurrence, but prolonged therapy can cause serious bleeding. Ideally, treatment duration should be tailored to individual patients but can this be achieved with ultrasonography, as proposed by the AESOPUS group?
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References
Samama, M. M. An epidemiologic study of risk factors for deep vein thrombosis in medical outpatients: the Sirius study. Arch. Intern. Med. 160, 3415–3420 (2000).
Bounameaux, H. & Perrier, A. Duration of anticoagulation therapy for venous thromboembolism. Hematology Am. Soc. Hematol. Educ. Program 252–258 (2008).
Prandoni, P. et al. Residual thrombosis on ultrasonography to guide the duration of anticoagulation in patients with deep venous thrombosis: a randomized trial. Ann. Intern. Med. 150, 577–585 (2009).
Kearon, C. et al. Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) Chest 133, 454S–545S (2008).
Prandoni, P. et al. Residual venous thrombosis as a predictive factor of recurrent venous thromboembolism. Ann. Intern. Med. 137, 955–960 (2002).
Cosmi, B., Legnani, C., Cini, M., Guazzaloca, G. & Palareti, G. D-dimer levels in combination with residual venous obstruction and the risk of recurrence after anticoagulation withdrawal for a first idiopathic deep vein thrombosis. Thromb. Haemost. 94, 969–974 (2005).
Siragusa, S. et al. Residual vein thrombosis to establish duration of anticoagulation after a first episode of deep vein thrombosis: the Duration of Anticoagulation based on Compression UltraSonography (DACUS) study. Blood 112, 511–515 (2008).
Cosmi, B. et al. Residual venous obstruction and D-dimer as risk factors for recurrence after anticoagulation withdrawal for a first idiopathic deep vein thrombosis in the PROLONG study. Haematologica 93 (Suppl. 3), 71 (2008).
Spencer, F. A. et al. Patient outcome after deep vein thrombosis and pulmonary embolism: the Worcester Venous Thromboembolism Study. Arch. Intern. Med. 168, 425–430 (2008).
Ruíz-Giménez, N. et al. Predictive variables for major bleeding events in patients presenting with documented acute venous thromboembolism. Findings from the RIETE Registry. Thromb. Haemost. 100, 26–31 (2008).
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Bounameaux, H., Righini, M. Duration of anticoagulation after VTE: guided by ultrasound?. Nat Rev Cardiol 6, 499–500 (2009). https://doi.org/10.1038/nrcardio.2009.116
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DOI: https://doi.org/10.1038/nrcardio.2009.116