Old materials, new challenges?

Fumed silica has been used as an anti-caking agent in foods for several decades. Does new research suggest that the use of this engineered nanomaterial needs to be re-examined, asks Andrew D. Maynard.

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  1. 1.

  2. 2.

  3. 3.

    European Commission Joint Research Centre Synthetic Amorphous Silicon Dioxide (NM-200, NM-201, NM-202, NM-203, NM-204): Characterisation and Physico-Chemical Properties. JRC Scientific and Policy Reports, JRC 83506 (Publications Office of the European Union, 2013).

  4. 4.

    Code of Federal Regulations Title 21, Vol. 3, 21CFR172.480 (US FDA, 2013);

  5. 5.

    European Center for Ecotoxicology and Toxicology of Chemicals Synthetic Amorphous Silica (CAS No. 7631-86-9), JACC No. 51 (ECETOC, 2006); available at

  6. 6.

    Synthetic Amorphous Silica and Silicates Industry Association Nanoscale Materials Stewardship Program (NMSP) Voluntary Submittal Package for Synthetic Amorphous Silica CAS No. 7631-86-9 (SASSI, 2008);

  7. 7.

    et al. J. Am. Chem. Soc. 134, 15790–15804 (2012).

  8. 8.

    et al. Part. Fibre Toxicol. 11, 8 (2014).

  9. 9.

    Nature Nanotech. 9, 409–410 (2014).

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Author information


  1. Andrew D. Maynard is at the Risk Science Center, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, Michigan 48109, USA

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Corresponding author

Correspondence to Andrew D. Maynard.