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Neddylation is needed for synapse maturation

Nature Neuroscience volume 18, pages 164–166 (2015)Cite this article

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A study reports for the first time on the importance of post-translational modification by neddylation in postnatal brain development. In particular, it is critical to synapse maturation and stability, and thus to cognition.

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Figure 1: Inhibition of neddylation compromises dendritic spine stability, synapse maturation and cognitive function.

Katie Vicari/Nature Publishing Group

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Authors and Affiliations

  1. Amy K. Fu and Nancy Y. Ip are in the Division of Life Science, Molecular Neuroscience Center, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.,

    Amy K Fu & Nancy Y Ip

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  1. Amy K Fu
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  2. Nancy Y Ip
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Correspondence to Nancy Y Ip.

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The authors declare no competing financial interests.

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Fu, A., Ip, N. Neddylation is needed for synapse maturation. Nat Neurosci 18, 164–166 (2015). https://doi.org/10.1038/nn.3929

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