A study finds that the loss of phasic dopamine signal in ventral, but not dorsal, striatum predicts escalation of cocaine self-administration. We discuss the study's implications for addiction theory and treatment.
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Clinically Combating Reward Deficiency Syndrome (RDS) with Dopamine Agonist Therapy as a Paradigm Shift: Dopamine for Dinner?
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Caprioli, D., Calu, D. & Shaham, Y. Loss of phasic dopamine: a new addiction marker?. Nat Neurosci 17, 644–646 (2014). https://doi.org/10.1038/nn.3699
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DOI: https://doi.org/10.1038/nn.3699
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