CNS white matter injury may cause sustained demyelination despite the persistence of oligodendrocyte progenitor cells (OPCs). A study suggests that dysregulated Wnt signaling disrupts self-renewal to yield OPC maturation arrest.
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Goldman, S., Osorio, J. So many progenitors, so little myelin. Nat Neurosci 17, 483–485 (2014). https://doi.org/10.1038/nn.3685
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DOI: https://doi.org/10.1038/nn.3685
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