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Fast-spiking interneurons have an initial orientation bias that is lost with vision

Nature Neuroscience volume 14, pages 1121–1123 (2011)Cite this article

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Abstract

We found that in mice, following eye opening, fast-spiking, parvalbumin-positive GABAergic interneurons had well-defined orientation tuning preferences and that subsequent visual experience broadened this tuning. Broad inhibitory tuning was not required for the developmental sharpening of excitatory tuning but did precede binocular matching of excitatory orientation tuning. We propose that experience-dependent broadening of inhibition is a candidate for initiating the critical period of excitatory binocular plasticity in developing visual cortex.

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Figure 1: Broadening of parvalbumin-positive interneuron tuning requires visual experience.
Figure 2: Inhibitory and excitatory tuning diverges with age and experience.

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Acknowledgements

We thank A. Silva for use of equipment and space, P. Golshani and D. Chow for technical training and discussion, D. Ringach and R. Gruver for help with data analysis, and T. Otis, S. Smith, M. Stryker and D. Ringach for comments on earlier versions of the manuscript. This work was supported by the US National Eye Institute (grants EY016052 and EY016052S2).

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  1. Department of Neurobiology, University of California, Los Angeles, Los Angeles, California, USA

    Sandra J Kuhlman, Elaine Tring & Joshua T Trachtenberg

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  1. Sandra J Kuhlman
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  2. Elaine Tring
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  3. Joshua T Trachtenberg
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Contributions

S.J.K. and J.T.T. designed the experiments and wrote the manuscript. S.J.K. carried out the parvalbumin-positive experiments and analyzed the data, and S.J.K. and E.T. carried out the RFP-negative experiments and analyzed the data.

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Correspondence to Joshua T Trachtenberg.

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The authors declare no competing financial interests.

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Supplementary Figures 1–7 and Methods (PDF 1203 kb)

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Kuhlman, S., Tring, E. & Trachtenberg, J. Fast-spiking interneurons have an initial orientation bias that is lost with vision. Nat Neurosci 14, 1121–1123 (2011). https://doi.org/10.1038/nn.2890

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