Application of single-molecule methods to assay genome-wide mRNA and protein levels in single bacteria provides a systems-level view of their relationship.
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References
Taniguchi, Y. et al. Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells. Science 329, 533–538 (2010).
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Evanko, D. Single molecules meet systems biology. Nat Methods 7, 672–673 (2010). https://doi.org/10.1038/nmeth0910-672a
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DOI: https://doi.org/10.1038/nmeth0910-672a