A normally undesirable property of chromophores is used in the creation of a genetically encoded tag for correlated light and electron microscopy.
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References
Shu, X. et al. A genetically encoded tag for correlated light and electron microscopy of intact cells, tissues, and organisms. PLoS Biol. 9, e1001041 (2011).
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Evanko, D. The right chromophore for the job. Nat Methods 8, 448–449 (2011). https://doi.org/10.1038/nmeth0611-448a
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DOI: https://doi.org/10.1038/nmeth0611-448a