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HIV-1 induction of CD40 on endothelial cells promotes the outgrowth of AIDS-associated B-cell lymphomas

Nature Medicine volume 3, pages 1242–1249 (1997)Cite this article

Abstract

Human immunodeficiency virus (HIV)-I infection is associated with the development of aggressive extranodal B-cell non-Hodgkin's lymphomas. Using microvascular endothelial cell (MVEC)-enriched bone marrow stromal cultures, HIV infection of stromal MVECs from lymphoma patients induced the outgrowth of malignant B cells. MVECs were the only HIV-infected cells in the stroma, and purified brain MVECs also induced a phenotype supportive of neoplastic B-cell attachment and proliferation. HIV infection of MVECs stimulated surface expression of CD40 and allowed preferential induction of the vascular cell adhesion molecule VCAM-1 after CD40 triggering. B-lymphoma cells expressed the CD40 ligand (CD40L), and blocking of CD40–CD40L interactions between HIV-infected MVECs and B-lymphoma cells inhibited B-cell attachment and proliferation. These observations suggest that HIV promotes B-lymphoma cell growth through facilitating attachment of lymphoma cells to HIV-infected MVECs and represent a novel mechanism through which viruses may induce malignancies.

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Author information

Authors and Affiliations

  1. Department of Molecular Microbiology and Immunology, L220, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, Oregon, 97201–3011, USA

    Ashlee V. Moses, Sally E. Williams, Joanne G. Strussenberg, Rebecca A. Ruhl & Jay A. Nelson

  2. Departments of Medicine and Molecular and Medical Genetics, L580, Oregon Health Sciences University and Veterans Affairs Medical Center, 3181 SW Sam Jackson Park Road, Portland, Oregon, 97201–3011, USA

    Marika L. Heneveld & Grover C. Bagby

  3. Departments of Pathology and Molecular Microbiology and Immunology, L471, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, Oregon, 97201–3011, USA

    Antony C. Bakke

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Moses, A., Williams, S., Strussenberg, J. et al. HIV-1 induction of CD40 on endothelial cells promotes the outgrowth of AIDS-associated B-cell lymphomas. Nat Med 3, 1242–1249 (1997). https://doi.org/10.1038/nm1197-1242

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