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Microarrays: retracing steps

Nature Medicine volume 13, pages 1276–1277 (2007)Cite this article

To the editor:

Recently, Potti et al.1 published an article in Nature Medicine reporting an approach predicting whether a tumor will respond to chemotherapy. Using publicly available data, they derived signatures from microarray profiles of the NCI-60 human cancer cell lines with known in vitro sensitivity or resistance to a particular drug. They used these profiles to predict in vivo chemotherapeutic response to seven different drugs. In order to help investigators at our institution use similar approaches, we tried to reproduce their results. We used the same published data and additional information generously supplied by the authors regarding methods, lists of cell lines called sensitive or resistant, and the software used to perform their analysis.

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Figure 1: Plot of the first two principal components from the NCI-60 training set for docetaxel, into which the validation set from Chang et al.2 has been projected.

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References

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  1. Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, Houston, 77030, Texas, USA

    Kevin R Coombes, Jing Wang & Keith A Baggerly

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  1. Kevin R Coombes
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  2. Jing Wang
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  3. Keith A Baggerly
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Coombes, K., Wang, J. & Baggerly, K. Microarrays: retracing steps. Nat Med 13, 1276–1277 (2007). https://doi.org/10.1038/nm1107-1276b

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