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Mental illness and the sciences of brain and behavior

Nature Medicine volume 5, pages 1113–1116 (1999)Cite this article

In 1942, studying shock as a National Research Council fellow at Harvard with Joseph Aub, I became interested in the remarkable homeostatic reflexes that serve to preserve the flow of blood to the brain1, an interest that was enhanced when I saw a paper by Dumke and Schmidt in which the circulation of blood to the brain was measured for the first time by means of a flow meter inserted directly into the cerebral arteries of an anesthetized rhesus monkey. When my fellowship was over I received a position in Carl Schmidt's laboratory, assisting him in further studies of perfusion and oxygen consumption in the monkey brain. Although the results were the first measurements made in a mammalian brain, I was somehow left unsatisfied.

Human cerebral circulation

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Figure 1: Autoradiogram of brain of a cat (a) resting and (b) during photic stimulation.
Figure 2: Regional blood flow in the human brain defined by PET scans using the autoradiographic technique with 15O water as a tracer7.

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  1. McLean Hospital, 115 Mill Street, Belmont, 02478, MA

    Seymour S. Kety

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Kety, S. Mental illness and the sciences of brain and behavior. Nat Med 5, 1113–1116 (1999). https://doi.org/10.1038/13427

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