The HIV drug raltegravir, which blocks viral integration into the genome, results in a transient increase in episomes, circularized HIV DNA. The findings suggest that persistent HIV replication occurs in people on antiretroviral therapy. Measuring episomes may also offer a new method to study viral persistence and latency and to gauge the effectiveness of antiviral regimens (pages 460–465).
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Schacker, T. New tools to track HIV. Nat Med 16, 373–374 (2010). https://doi.org/10.1038/nm0410-373
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DOI: https://doi.org/10.1038/nm0410-373
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