Microarray analysis can be used to differentiate gene expression patterns between various types of tumors, including breast tumors caused by BRCA1 and BRCA2 mutations. But what must be done before this technology can be used in the clinic?
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Alizadeh, A.A. et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403, 503–511 (2000).
Perou, C.M. et al. Molecular portraits of human breast tumours. Nature 406, 747–752 (2000).
Hedenfalk, I. et al. Gene-expression profiles in hereditary breast cancer. N. Engl. J. Med. 344, 539–548. (2001).
Ford, D., Easton, D.F., Bishop, D.T., Narod, S.A. & Goldgar, D.E. Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. Lancet 343, 692–695 (1994).
Breast Cancer Linkage Consortium. Pathology of familial breast cancer: differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases. BCLC. Lancet 349, 1505–1510 (1997).
Lakhani, S.R. et al. Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations. J. Natl. Cancer Inst. 90, 1138–1145 (1998).
Johannsson, O.T. et al. Tumour biological features of BRCA1-induced breast and ovarian cancer. Eur. J. Cancer 33, 362–371 (1997)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lakhani, S., O'Hare, M. & Ashworth, A. Profiling familial breast cancer. Nat Med 7, 408–410 (2001). https://doi.org/10.1038/86464
Issue Date:
DOI: https://doi.org/10.1038/86464
This article is cited by
-
BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer
Breast Cancer Research and Treatment (2010)
-
Basal-like breast cancer and the BRCA1 phenotype
Oncogene (2006)
-
Hallmarks of 'BRCAness' in sporadic cancers
Nature Reviews Cancer (2004)