Cancer cachexia leads to involuntary weight loss resulting from the atrophy of skeletal muscle and adipose tissues. Now, in metastatic mouse models of cancer, investigators reveal a cross talk pathway between bone and muscle that provides a new understanding of wasting in advanced cancers.
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IMB0901 inhibits muscle atrophy induced by cancer cachexia through MSTN signaling pathway
Skeletal Muscle Open Access 28 March 2019
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Guttridge, D. A TGF-β pathway associated with cancer cachexia. Nat Med 21, 1248–1249 (2015). https://doi.org/10.1038/nm.3988
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DOI: https://doi.org/10.1038/nm.3988
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IMB0901 inhibits muscle atrophy induced by cancer cachexia through MSTN signaling pathway
Skeletal Muscle (2019)