Inhibition of phagocyte activity depends on the ligation of SIRP-α by CD47. New findings show that Sirpa polymorphisms influence the engraftment and tolerance of xenogeneic transplants in NOD-SCID mice.
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Takizawa, H., Manz, M. Macrophage tolerance: CD47–SIRP-α–mediated signals matter. Nat Immunol 8, 1287–1289 (2007). https://doi.org/10.1038/ni1207-1287
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DOI: https://doi.org/10.1038/ni1207-1287
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