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'PPAR'ting ways with inflammation

Nature Immunology volume 6, pages 966–967 (2005)Cite this article

Although it often acts as a transcriptional activator, the nuclear hormone receptor PPAR-γ also 'transrepresses' inflammatory responses mediated by the transcription factor NF-κB. New data demonstrate that sumoylation of PPAR-γ leads to the retention of repressor complexes on promoters of inflammatory genes.

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Figure 1: Transrepression by PPAR-γ.

References

  1. Pascual, G. et al. Nature advance online publication, 28 August 2005 (10.1038/nature0398).

  2. Ricote, M., Li, A.C., Willson, T.M., Kelly, C.J. & Glass, C.K. Nature 391, 79–82 (1998).

    Article  CAS  Google Scholar 

  3. Jiang, C., Ting, A.T. & Seed, B. Nature 391, 82–86 (1998).

    Article  CAS  Google Scholar 

  4. Daynes, R.A. & Jones, D.C. Nat. Rev. Immunol. 2, 748–759 (2002).

    Article  CAS  Google Scholar 

  5. De Bosscher, K. et al. Proc. Natl. Acad. Sci. USA 97, 3919–3924 (2000).

    Article  CAS  Google Scholar 

  6. Scheinman, R.I., Gualberto, A., Jewell, C.M., Cidlowski, J.A. & Baldwin, A.S., Jr. Mol. Cell Biol. 15, 943–953 (1995).

    Article  CAS  Google Scholar 

  7. Ogawa, S. et al. Proc. Natl. Acad. Sci. USA 101, 14461–14466 (2004).

    Article  CAS  Google Scholar 

  8. Li, M., Pascual, G. & Glass, C.K. Mol. Cell Biol. 20, 4699–4707 (2000).

    Article  CAS  Google Scholar 

  9. Tan, J. et al. Mol. Endocrinol. 14, 14–26 (2000).

    Article  CAS  Google Scholar 

  10. Tallec, L.P. et al. Mol. Endocrinol. 17, 2529–2542 (2003).

    Article  Google Scholar 

  11. Yamashita, D. et al. Genes Cells 9, 1017–1029 (2004).

    Article  CAS  Google Scholar 

  12. Ohshima, T., Koga, H. & Shimotohno, K. J. Biol. Chem. 279, 29551–29557 (2004).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Section of Immunobiology and Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, 06519, Connecticut, USA

    Shannon T Bailey & Sankar Ghosh

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  1. Shannon T Bailey
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  2. Sankar Ghosh
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Bailey, S., Ghosh, S. 'PPAR'ting ways with inflammation. Nat Immunol 6, 966–967 (2005). https://doi.org/10.1038/ni1005-966

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