Certain infectious diseases, autoimmune disorders and cancers are associated with T cell receptor ζ chain down-regulation. Interferon-γ production by T helper type 1 cells seems to be pivotal in this process.
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Poli, G., Bordignon, C. Unplugging the T cell receptor. Nat Immunol 4, 943–944 (2003). https://doi.org/10.1038/ni1003-943
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DOI: https://doi.org/10.1038/ni1003-943
