A deficit of caspase-8 should presumably lead to over-activation of lymphocytes. A recent report in Nature from Lenardo's group, however, describes humans with a severe caspase-8 deficiency whose T cells, counter-intuitively, have impaired activation abilities.
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Barnhart, B., Peter, M. Two faces of caspase-8. Nat Immunol 3, 896–898 (2002). https://doi.org/10.1038/ni1002-896
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DOI: https://doi.org/10.1038/ni1002-896
