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Regulatory T cells that become autoaggressive

Nature Immunology volume 10, pages 938–939 (2009)Cite this article

Foxp3 expression is not stable and may be extinguished both in vitro and in vivo in regulatory T cells that convert into proinflammatory effector T cells. The loss of Foxp3 in regulatory T cells under autoimmune conditions may result in the conversion of suppressor T cells into highly autoaggressive lymphocytes.

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Figure 1: Loss of Foxp3 in some Treg cells under autoimmune conditions may result in the conversion of former suppressor T cells into highly autoaggressive lymphocytes.

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Authors and Affiliations

  1. Daniel Hawiger is in the Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.,

    Daniel Hawiger

  2. Richard A. Flavell is in the Department of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA.,

    Richard A Flavell

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  1. Daniel Hawiger
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  2. Richard A Flavell
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Correspondence to Richard A Flavell.

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Hawiger, D., Flavell, R. Regulatory T cells that become autoaggressive. Nat Immunol 10, 938–939 (2009). https://doi.org/10.1038/ni0909-938

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