Members of the Toll-like receptor–interleukin 1 receptor superfamily signal inflammatory responses. However, a member of this family is now shown to modulate these responses by acting as a negative regulator.
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O'Neill, L. SIGIRR puts the brakes on Toll-like receptors. Nat Immunol 4, 823–824 (2003). https://doi.org/10.1038/ni0903-823
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DOI: https://doi.org/10.1038/ni0903-823
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