Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

“Decisions, decisions ...”: β-catenin–mediated activation of TCF-1 and Lef-1 influences the fate of developing T cells

Nature Immunology volume 2, pages 823–824 (2001)Cite this article

Successful passage through several developmental checkpoints determines whether thymocytes survive, proliferate or differentiate. New data show that Wnt-frizzled–induced activation of TCF-1 or Lef-1, via their coactivator β-catenin, is critical during TCRB and TCRA gene rearrangement in thymocytes.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Role of surface receptors and transcription factors in the control of T cell development.

Bob Crimi

References

  1. Aifantis, I. et al. Nature Immunol. 2, 403–409 (2001).

    Article  CAS  Google Scholar 

  2. Ioannidis, V. et al. Nature Immunol. 2, 691–697 (2001)

    Article  CAS  Google Scholar 

  3. Gounari, F. et al. Nature Immunol. 2, 863–869 (2001).

    Article  CAS  Google Scholar 

  4. Staal, F. J. et al. Eur. J. Immunol. 31, 285–293 (2001).

    Article  CAS  PubMed  Google Scholar 

  5. Okamura, R. M. et al. Immunity 8, 11–20 (1998).

    Article  CAS  PubMed  Google Scholar 

  6. Strasser, A., O'Connor, L. & Dixit, V. M. Annu. Rev. Biochem. 69, 217–245 (2000).

    Article  CAS  PubMed  Google Scholar 

  7. Strasser, A. et al. EMBO J. 14, 6136–6147 (1995).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Bouillet, P. et al. Science 286, 1735–1738 (1999).

    Article  CAS  PubMed  Google Scholar 

  9. Maraskovsky, E. et al. Cell 89, 1011–1019 (1997).

    Article  CAS  PubMed  Google Scholar 

  10. Haks, M. C. et al. Immunity 11, 91–101 (1999).

    Article  CAS  PubMed  Google Scholar 

  11. Newton, K., Harris, A. W. & Strasser, A. EMBO J. 19, 931–941 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Kabra, N. H et al. Proc. Natl Acad. Sci. USA 98, 6307–6312 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Winandy, S. et al. J. Exp. Med. 190, 1039–1048 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Newton, K. et al. EMBO J. 17, 706–718 (1998).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Zhang, J. et al. Nature 392, 296–300 (1998).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Walter and Eliza Hall Institute, Post Office Royal Melbourne Hospital, 3050 Vic, Australia, Melbourne, Australia

    Li Wu & Andreas Strasser

Authors
  1. Li Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andreas Strasser
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wu, L., Strasser, A. “Decisions, decisions ...”: β-catenin–mediated activation of TCF-1 and Lef-1 influences the fate of developing T cells. Nat Immunol 2, 823–824 (2001). https://doi.org/10.1038/ni0901-823

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0901-823

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing