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Arrestin NK cell cytotoxicity

A key regulator of the balance of signals that activate effector mechanisms versus those that restrain them, β-arrestin 2 mediates the inhibition of natural killer cell cytotoxicity.

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Figure 1: Two models for inhibitory signaling pathways by KIRs.

Katie Ris-Vicari

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Bryceson, Y., Ljunggren, HG. Arrestin NK cell cytotoxicity. Nat Immunol 9, 835–836 (2008). https://doi.org/10.1038/ni0808-835

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