Perturbation of T cell differentiation by overexpression of SCL and LMO can lead to leukemia. This dysregulation may be initiated by inactivation of E2A.
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Bob Crimi
References
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Murre, C. Intertwining proteins in thymocyte development and cancer. Nat Immunol 1, 97–98 (2000). https://doi.org/10.1038/77881
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DOI: https://doi.org/10.1038/77881
