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CSF-1R, DAP12 and β-catenin: a ménage à trois

Nature Immunology volume 10, pages 681–683 (2009)Cite this article

DAP12-coupled receptors influence signals emanating from Toll-like receptors, integrins and receptors for cytokines and growth factors. New findings indicate that DAP12 also facilitates the ability of CSF-1R, the receptor for M-CSF, to induce the stabilization and nuclear translocation of β-catenin.

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Figure 1: Proposed crosstalk among CSF-1R, DAP12 and β-catenin.

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Authors and Affiliations

  1. Daniel W. McVicar and Giorgio Trinchieri are with the Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland, USA. e-mail: trinchig@mail.nih.gov,

    Daniel W McVicar & Giorgio Trinchieri

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  1. Daniel W McVicar
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  2. Giorgio Trinchieri
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McVicar, D., Trinchieri, G. CSF-1R, DAP12 and β-catenin: a ménage à trois. Nat Immunol 10, 681–683 (2009). https://doi.org/10.1038/ni0709-681

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