CIITA encodes the 'master regulator' of the expression of major histocompatibility complex class II genes. A new layer of complexity has been identified in the control of CIITA expression, which involves the formation of a complex three-dimensional chromatin structure promoted by interactions among many distant regulatory elements.
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References
Steimle, V., Otten, L.A., Zufferey, M. & Mach, B. Cell 75, 135–146 (1993).
Wright, K.L. & Ting, J.P. Trends Immunol. 27, 405–412 (2006).
Leibundgut-Landmann, S. et al. Eur. J. Immunol. 34, 1513–1525 (2004).
Ni, Z., Abou El Hassan, M., Xu, Z., Yu, T. & Bremner, R. Nat. Immunol. 9, 785–793 (2008).
Muhlethaler-Mottet, A., Otten, L.A., Steimle, V. & Mach, B. EMBO J. 16, 2851–2860 (1997).
LeibundGut-Landmann S., Waldburger, J.M., Reis e Sousa, C., Acha-Orbea, H. & Reith, W. Nat. Immunol. 5, 899–908 (2004).
Waldburger, J.M., Suter, T., Fontana, A., Acha-Orbea, H. & Reith, W. J. Exp. Med. 19, 393–406 (2001).
Mudhasani, R. & Fontes, J.D. Mol. Cell. Biol. 22, 5019–5026 (2002).
Pattenden, S.G., Klose, R., Karaskov, E. & Bremner, R. EMBO J. 21, 1978–1986 (2002).
Morris, A.C., Beresford, G.W., Mooney, M.R. & Boss, J.M. Mol. Cell. Biol. 22, 4781–4791 (2002).
de Laat, W. & Grosveld, F. Chromosome Res. 11, 447–459 (2003).
Schoenborn, J.R. et al. Nat. Immunol. 8, 732–742 (2007).
Majumder, P., Gomez, J.A., Chadwick, B.P. & Boss, J.M. J. Exp. Med. 205, 785–798 (2008).
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Reith, W., Boss, J. New dimensions of CIITA. Nat Immunol 9, 713–714 (2008). https://doi.org/10.1038/ni0708-713
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DOI: https://doi.org/10.1038/ni0708-713
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