How do cells fend off intracellular viruses that slip in below extracellular defensive 'radar screens'? The identification of a cytoplasmic RNA helicase that signals through CARD interactions links viral detection to the interferon-β induction pathway.
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References
Levy, D.E., Marié, I. & Prakash, A. Curr. Opin. Immunol. 15, 52–58 (2003).
Yoneyama, M. et al. EMBO J. 17, 1087–1095 (1998).
Yoneyama, M. et al. Nat. Immunol. 5, 730–737 (2004).
Yang, Y.L. et al. EMBO J. 14, 6095–6106 (1995).
Honda, K. et al. Proc. Natl. Acad. Sci. USA 100, 10872–10877 (2003).
Smith, A.E. & Helenius, A. Science 304, 237–242 (2004).
tenOever, B.R., Servant, M.J., Grandvaux, N., Lin, R. & Hiscott, J. J. Virol. 76, 3659–3669 (2002).
Hofmann, K., Bucher, P. & Tschopp, J. Trends Biochem. Sci 22, 155–156 (1997).
Kobayashi, K. et al. Nature 416, 194–199 (2002).
Fitzgerald, K.A. et al. Nat. Immunol. 4, 491–496 (2003).
Sharma, S. et al. Science 300, 1148–1151 (2003).
Fairman, M.E. et al. Science 304, 730–734 (2004).
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Levy, D., Marié, I. RIGging an antiviral defense—it's in the CARDs. Nat Immunol 5, 699–701 (2004). https://doi.org/10.1038/ni0704-699
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DOI: https://doi.org/10.1038/ni0704-699
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