Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

IL-17A directly inhibits TH1 cells and thereby suppresses development of intestinal inflammation

Nature Immunology volume 10, pages 568–570 (2009)Cite this article

T helper type 1 cells (TH1 cells) serve a dominant function in T cell–mediated colitis. New work reports that interleukin 17A, an effector cytokine required for the development of autoimmune tissue inflammation, directly inhibits TH1 development by suppressing the expression of key TH1-associated genes and therefore regulates TH1 cell–mediated colitis.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: IL-17-mediated cross-regulation of the effector TH1 response.

References

  1. Izcue, A. et al. Immunol. Rev. 212, 256–271 (2006).

    Article  CAS  Google Scholar 

  2. Weiner, H.L. Nat. Immunol. 2, 671–672 (2003).

    Article  Google Scholar 

  3. O'Connor, W. Jr. et al. Nat Immunol. 10, 603–609 (2009).

    Article  CAS  Google Scholar 

  4. Kuhn, R. et al. Cell 75, 263–274 (1993).

    Article  CAS  Google Scholar 

  5. Rubtsov, Y.P. et al. Immunity 28, 546–558 (2008).

    Article  CAS  Google Scholar 

  6. Ito, H. et al. J. Autoimmun. 10, 455–459 (1997).

    Article  CAS  Google Scholar 

  7. Bettelli, E. et al. Nature 453, 1051–1057 (2008).

    Article  CAS  Google Scholar 

  8. Awasthi, A. et al. J. Immunol. (in the press).

  9. Duerr, R.H. et al. Science 314, 1461–1463 (2006).

    Article  CAS  Google Scholar 

  10. Yen, D. et al. J. Clin. Invest. 116, 1310–1316 (2006).

    Article  CAS  Google Scholar 

  11. Rangachari, M. et al. J. Exp. Med. 203, 2009–2019 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Amit Awasthi & Vijay K Kuchroo

Authors
  1. Amit Awasthi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Vijay K Kuchroo
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Awasthi, A., Kuchroo, V. IL-17A directly inhibits TH1 cells and thereby suppresses development of intestinal inflammation. Nat Immunol 10, 568–570 (2009). https://doi.org/10.1038/ni0609-568

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0609-568

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing